Drug interactions
Carbamazepine + Medroxyprogesterone
Severity: Moderate
Carbamazepine and Medroxyprogesterone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine induces hepatic enzymes and can lower medroxyprogesterone concentrations, possibly reducing contraceptive efficacy. Unintended pregnancy is a concern with this teratogenic antiepileptic.
What this interaction means in plain words
Carbamazepine and Medroxyprogesterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbamazepine belongs to Central Nervous System; Medroxyprogesterone belongs to Endocrine.
Why it happens
Carbamazepine induces CYP3A4, increasing the clearance of medroxyprogesterone.
What to do
Counsel patients about possible reduced contraceptive efficacy and consider shortening the injection interval or adding a non-hormonal method. Review contraception whenever carbamazepine is started or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Other interactions of Medroxyprogesterone
Frequently asked questions
Can I take Carbamazepine with Medroxyprogesterone?
MediHelp rates the interaction as moderate. Carbamazepine and Medroxyprogesterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine induces hepatic enzymes and can lower medroxyprogesterone concentrations, possibly reducing contraceptive efficacy. Unintended pregnancy is a concern with this teratogenic antiepileptic.
How serious is the interaction between Carbamazepine and Medroxyprogesterone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about possible reduced contraceptive efficacy and consider shortening the injection interval or adding a non-hormonal method. Review contraception whenever carbamazepine is started or stopped.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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