Drug interactions
Carbamazepine + Propofol
Severity: Minor
Carbamazepine and Propofol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine may modestly increase propofol clearance, possibly increasing anesthetic requirements. The effect is typically small, and propofol is titrated to effect.
What this interaction means in plain words
Carbamazepine and Propofol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Carbamazepine belongs to Central Nervous System; Propofol belongs to Central Nervous System.
Why it happens
Carbamazepine induces CYP2B6 and other metabolic pathways, including glucuronidation, involved in propofol clearance.
What to do
No empirical dose change is needed. Titrate propofol to clinical effect and depth of anesthesia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Other interactions of Propofol
Frequently asked questions
Can I take Carbamazepine with Propofol?
MediHelp rates the interaction as minor. Carbamazepine and Propofol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Carbamazepine may modestly increase propofol clearance, possibly increasing anesthetic requirements. The effect is typically small, and propofol is titrated to effect.
How serious is the interaction between Carbamazepine and Propofol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed. Titrate propofol to clinical effect and depth of anesthesia.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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