Drug interactions
Carbamazepine + Secukinumab
Severity: Minor
Carbamazepine and Secukinumab: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Secukinumab neutralizes IL-17A and may normalize CYP expression suppressed by inflammation. This could theoretically lower carbamazepine concentrations in patients with inflammatory disease, but no clinically important effect is established.
What this interaction means in plain words
Carbamazepine and Secukinumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Carbamazepine belongs to Central Nervous System; Secukinumab belongs to Miscellaneous.
Why it happens
Reduction of cytokine-mediated CYP suppression may increase CYP3A4 activity; the effect is theoretical.
What to do
Check carbamazepine concentrations and clinical response when secukinumab is started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Other interactions of Secukinumab
- Adenovirus types 4 and 7 live + Secukinumab Major
- Bcg vaccine live + Secukinumab Major
- Influenza virus vaccine quadrivalent intranasal + Secukinumab Major
- Measles mumps and rubella vaccine live + Secukinumab Major
- Measles mumps and rubella vaccine + Secukinumab Major
- Measles mumps rubella and varicella vaccine live + Secukinumab Major
Frequently asked questions
Can I take Carbamazepine with Secukinumab?
MediHelp rates the interaction as minor. Carbamazepine and Secukinumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Secukinumab neutralizes IL-17A and may normalize CYP expression suppressed by inflammation. This could theoretically lower carbamazepine concentrations in patients with inflammatory disease, but no clinically important effect is established.
How serious is the interaction between Carbamazepine and Secukinumab?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check carbamazepine concentrations and clinical response when secukinumab is started or stopped.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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