Drug interactions
Carbamazepine + Vilazodone
Severity: Moderate
Carbamazepine and Vilazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine is a strong CYP3A4 inducer and substantially lowers vilazodone exposure. This may lead to loss of antidepressant effect.
What this interaction means in plain words
Carbamazepine and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbamazepine belongs to Central Nervous System; Vilazodone belongs to Central Nervous System.
Why it happens
Carbamazepine induces CYP3A4, accelerating vilazodone metabolism.
What to do
Monitor clinical response and consider titrating vilazodone upward, up to about twofold, within the labeled maximum if the combination continues beyond about two weeks. Reduce the vilazodone dose back to its usual level when carbamazepine is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Carbamazepine with Vilazodone?
MediHelp rates the interaction as moderate. Carbamazepine and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine is a strong CYP3A4 inducer and substantially lowers vilazodone exposure. This may lead to loss of antidepressant effect.
How serious is the interaction between Carbamazepine and Vilazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and consider titrating vilazodone upward, up to about twofold, within the labeled maximum if the combination continues beyond about two weeks. Reduce the vilazodone dose back to its usual level when carbamazepine is stopped.
What other medicines interact with Vilazodone?
MediHelp also lists interactions of Vilazodone with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Vilazodone page.
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