Drug interactions
Carfilzomib + Tucatinib
Severity: Minor
Carfilzomib and Tucatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib inhibits P-glycoprotein and may increase exposure to P-gp substrates. Carfilzomib is mainly cleared by peptidases, so any increase is likely modest.
What this interaction means in plain words
Carfilzomib and Tucatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Carfilzomib belongs to Oncology; Tucatinib belongs to Oncology.
Why it happens
Tucatinib inhibits P-gp efflux, which may modestly increase carfilzomib exposure.
What to do
No empirical dose change is needed; monitor for carfilzomib toxicity and reduce the dose if adverse effects emerge.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Carfilzomib
- Carfilzomib + Etrasimod Major
- Carfilzomib + Ropeginterferon alfa 2b Major
- Carfilzomib + Dichlorphenamide Moderate
- Carfilzomib + Palifermin Moderate
- Carfilzomib + Ponesimod Moderate
- Carfilzomib + Siponimod Moderate
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Carfilzomib with Tucatinib?
MediHelp rates the interaction as minor. Carfilzomib and Tucatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tucatinib inhibits P-glycoprotein and may increase exposure to P-gp substrates. Carfilzomib is mainly cleared by peptidases, so any increase is likely modest.
How serious is the interaction between Carfilzomib and Tucatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed; monitor for carfilzomib toxicity and reduce the dose if adverse effects emerge.
What other medicines interact with Carfilzomib?
MediHelp also lists interactions of Carfilzomib with, for example, Etrasimod, Ropeginterferon alfa 2b, Dichlorphenamide. The full list is on the Carfilzomib page.
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