Drug interactions
Caspofungin + Nevirapine
Severity: Moderate
Caspofungin and Nevirapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine may lower caspofungin concentrations and could compromise antifungal efficacy. Caspofungin labeling lists nevirapine among inducers for which a higher dose may be considered.
What this interaction means in plain words
Caspofungin and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Caspofungin belongs to Anti Fungals; Nevirapine belongs to Anti Virals.
Why it happens
Proposed induction of caspofungin clearance by nevirapine; the exact mechanism is not firmly established.
What to do
Consider increasing caspofungin to 70 mg daily in adults if the response is inadequate, and monitor clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Caspofungin
- Apalutamide + Caspofungin Moderate
- Carbamazepine + Caspofungin Moderate
- Caspofungin + Cyclosporin Moderate
- Caspofungin + Cyclosporine Moderate
- Caspofungin + Dexamethasone Moderate
- Caspofungin + Efavirenz Moderate
Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Frequently asked questions
Can I take Caspofungin with Nevirapine?
MediHelp rates the interaction as moderate. Caspofungin and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nevirapine may lower caspofungin concentrations and could compromise antifungal efficacy. Caspofungin labeling lists nevirapine among inducers for which a higher dose may be considered.
How serious is the interaction between Caspofungin and Nevirapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider increasing caspofungin to 70 mg daily in adults if the response is inadequate, and monitor clinical response.
What other medicines interact with Caspofungin?
MediHelp also lists interactions of Caspofungin with, for example, Apalutamide, Carbamazepine, Cyclosporin. The full list is on the Caspofungin page.
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