Drug interactions
Cefpirome + Furosemide
Severity: Minor
Cefpirome and Furosemide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loop diuretics combined with some cephalosporins have been associated with a greater risk of kidney injury, particularly when the patient is volume depleted. Evidence for cefpirome specifically is limited, and the effect is mostly theoretical with modern fourth-generation cephalosporins.
What this interaction means in plain words
Cefpirome and Furosemide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cefpirome belongs to Anti Bacterial; Furosemide belongs to Cardiovascular.
Why it happens
Diuretic-induced volume depletion may reduce renal perfusion and increase tubular exposure to the cephalosporin; the interaction is poorly established.
What to do
Maintain adequate hydration and monitor serum creatinine during combined therapy, especially in elderly or renally impaired patients. Adjust the cefpirome dose to renal function.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Other interactions of Cefpirome
- Amikacin + Cefpirome Moderate
- Bupropion-naltrexone + Cefpirome Moderate
- Bupropion + Cefpirome Moderate
- Cefpirome + Dexamethasone-tobramycin Moderate
- Cefpirome + Gentamicin Moderate
- Cefpirome + Streptomycin Moderate
Frequently asked questions
Can I take Cefpirome with Furosemide?
MediHelp rates the interaction as minor. Cefpirome and Furosemide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Loop diuretics combined with some cephalosporins have been associated with a greater risk of kidney injury, particularly when the patient is volume depleted. Evidence for cefpirome specifically is limited, and the effect is mostly theoretical with modern fourth-generation cephalosporins.
How serious is the interaction between Cefpirome and Furosemide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Maintain adequate hydration and monitor serum creatinine during combined therapy, especially in elderly or renally impaired patients. Adjust the cefpirome dose to renal function.
What other medicines interact with Furosemide?
MediHelp also lists interactions of Furosemide with, for example, Amifostine, Amikacin, Carbenoxolone. The full list is on the Furosemide page.
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