Drug interactions
Cefpirome + Piroxicam
Severity: Minor
Cefpirome and Piroxicam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cefpirome and piroxicam are both renally eliminated acidic drugs and could compete for tubular secretion, though cefpirome is largely cleared by filtration. Any rise in piroxicam levels is expected to be small.
What this interaction means in plain words
Cefpirome and Piroxicam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cefpirome belongs to Anti Bacterial; Piroxicam belongs to Musculoskeletal.
Why it happens
Theoretical competition for renal tubular secretion via anion transporters.
What to do
No action is required beyond awareness. Monitor renal function and NSAID adverse effects in vulnerable patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Other interactions of Cefpirome
- Amikacin + Cefpirome Moderate
- Bupropion-naltrexone + Cefpirome Moderate
- Bupropion + Cefpirome Moderate
- Cefpirome + Dexamethasone-tobramycin Moderate
- Cefpirome + Gentamicin Moderate
- Cefpirome + Streptomycin Moderate
Frequently asked questions
Can I take Cefpirome with Piroxicam?
MediHelp rates the interaction as minor. Cefpirome and Piroxicam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cefpirome and piroxicam are both renally eliminated acidic drugs and could compete for tubular secretion, though cefpirome is largely cleared by filtration. Any rise in piroxicam levels is expected to be small.
How serious is the interaction between Cefpirome and Piroxicam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is required beyond awareness. Monitor renal function and NSAID adverse effects in vulnerable patients.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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