Drug interactions
Celecoxib + Felbamate
Severity: Minor
Celecoxib and Felbamate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Felbamate inhibits CYP2C19 and may also affect CYP2C9, which might raise celecoxib levels. Data on this pair are limited.
What this interaction means in plain words
Celecoxib and Felbamate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Celecoxib belongs to Musculoskeletal; Felbamate belongs to Central Nervous System.
Why it happens
Possible inhibition of CYP2C9 metabolism of celecoxib by felbamate.
What to do
Monitor for celecoxib adverse effects and use the lowest effective dose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Felbamate
- Felbamate + Ulipristal Major
- Amisulpride + Felbamate Moderate
- Amitriptyline + Felbamate Moderate
- Apalutamide + Felbamate Moderate
- Asenapine + Felbamate Moderate
- Bosentan + Felbamate Moderate
Frequently asked questions
Can I take Celecoxib with Felbamate?
MediHelp rates the interaction as minor. Celecoxib and Felbamate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Felbamate inhibits CYP2C19 and may also affect CYP2C9, which might raise celecoxib levels. Data on this pair are limited.
How serious is the interaction between Celecoxib and Felbamate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for celecoxib adverse effects and use the lowest effective dose.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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