Drug interactions
Ceritinib + Digoxin
Severity: Major
Ceritinib and Digoxin: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both ceritinib and digoxin can slow heart rate and impair conduction. Combined use raises the risk of symptomatic bradycardia and heart block.
What this interaction means in plain words
Ceritinib and Digoxin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ceritinib belongs to Oncology; Digoxin belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic bradycardic and conduction-slowing effects.
What to do
Avoid combining where an alternative exists; otherwise monitor heart rate, ECG and digoxin levels regularly. Withhold or reduce ceritinib if bradycardia develops.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Ceritinib with Digoxin?
MediHelp rates the interaction as major. Ceritinib and Digoxin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both ceritinib and digoxin can slow heart rate and impair conduction. Combined use raises the risk of symptomatic bradycardia and heart block.
How serious is the interaction between Ceritinib and Digoxin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where an alternative exists; otherwise monitor heart rate, ECG and digoxin levels regularly. Withhold or reduce ceritinib if bradycardia develops.
What other medicines interact with Ceritinib?
MediHelp also lists interactions of Ceritinib with, for example, Cisapride, Eletriptan, Flibanserin. The full list is on the Ceritinib page.
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