Drug interactions
Ceritinib + Esomeprazole
Severity: Moderate
Ceritinib and Esomeprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceritinib solubility falls as gastric pH rises, so esomeprazole may lower its exposure and efficacy. The effect is more modest when ceritinib is taken with food.
What this interaction means in plain words
Ceritinib and Esomeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ceritinib belongs to Oncology; Esomeprazole belongs to Gastrointestinal Tract.
Why it happens
Higher gastric pH reduces the solubility and absorption of ceritinib.
What to do
Avoid the combination if possible. If a PPI is needed, reduce the ceritinib dose only as directed in the product labeling and monitor tumor response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esomeprazole
- Esomeprazole + Mavacamten Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Esomeprazole Major
- Atazanavir + Esomeprazole Major
- Citalopram + Esomeprazole Major
- Clopidogrel + Esomeprazole Major
Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Ceritinib with Esomeprazole?
MediHelp rates the interaction as moderate. Ceritinib and Esomeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ceritinib solubility falls as gastric pH rises, so esomeprazole may lower its exposure and efficacy. The effect is more modest when ceritinib is taken with food.
How serious is the interaction between Ceritinib and Esomeprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If a PPI is needed, reduce the ceritinib dose only as directed in the product labeling and monitor tumor response.
What other medicines interact with Esomeprazole?
MediHelp also lists interactions of Esomeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Esomeprazole page.
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