Drug interactions
Ceritinib + Linagliptin
Severity: Minor
Ceritinib and Linagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceritinib inhibits CYP3A4 and may increase linagliptin exposure. Because linagliptin is largely eliminated unchanged, the effect is likely small. Ceritinib itself can cause hyperglycemia.
What this interaction means in plain words
Ceritinib and Linagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ceritinib belongs to Oncology; Linagliptin belongs to Endocrine.
Why it happens
CYP3A4 inhibition by ceritinib modestly reduces linagliptin metabolism.
What to do
No dose change needed; monitor blood glucose given ceritinib-related hyperglycemia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Linagliptin
- Alogliptin-pioglitazone + Linagliptin Moderate
- Amlodipine-benazepril + Linagliptin Moderate
- Amobarbital + Linagliptin Moderate
- Apalutamide + Linagliptin Moderate
- Benazepril + Linagliptin Moderate
- Bexarotene + Linagliptin Moderate
Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Ceritinib with Linagliptin?
MediHelp rates the interaction as minor. Ceritinib and Linagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ceritinib inhibits CYP3A4 and may increase linagliptin exposure. Because linagliptin is largely eliminated unchanged, the effect is likely small. Ceritinib itself can cause hyperglycemia.
How serious is the interaction between Ceritinib and Linagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change needed; monitor blood glucose given ceritinib-related hyperglycemia.
What other medicines interact with Linagliptin?
MediHelp also lists interactions of Linagliptin with, for example, Alogliptin-pioglitazone, Amlodipine-benazepril, Amobarbital. The full list is on the Linagliptin page.
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