Drug interactions
Ceritinib + Modafinil
Severity: Minor
Ceritinib and Modafinil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceritinib inhibits CYP3A4 and may raise modafinil concentrations, although modafinil is only partly cleared by this pathway. Increased modafinil adverse effects such as anxiety, insomnia, headache and elevated blood pressure may occur.
What this interaction means in plain words
Ceritinib and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ceritinib belongs to Oncology; Modafinil belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4-mediated modafinil metabolism by ceritinib.
What to do
Monitor for modafinil adverse effects such as insomnia, anxiety and increased heart rate or blood pressure. Reduce the modafinil dose if adverse effects occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Modafinil
Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Ceritinib with Modafinil?
MediHelp rates the interaction as minor. Ceritinib and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ceritinib inhibits CYP3A4 and may raise modafinil concentrations, although modafinil is only partly cleared by this pathway. Increased modafinil adverse effects such as anxiety, insomnia, headache and elevated blood pressure may occur.
How serious is the interaction between Ceritinib and Modafinil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for modafinil adverse effects such as insomnia, anxiety and increased heart rate or blood pressure. Reduce the modafinil dose if adverse effects occur.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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