Drug interactions
Ceritinib + Ondansetron
Severity: Major
Ceritinib and Ondansetron: major interaction.
Last updated Sources: Health Canada product monograph
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceritinib prolongs the QT interval and also inhibits CYP3A4, which can raise ondansetron exposure. Both effects increase the risk of torsades de pointes.
What this interaction means in plain words
Ceritinib and Ondansetron can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ceritinib belongs to Oncology; Ondansetron belongs to Gastrointestinal Tract.
Why it happens
Additive QT prolongation, with CYP3A4 inhibition by ceritinib potentially raising ondansetron levels.
What to do
Avoid if possible and choose an antiemetic without QT effect. If used, monitor ECG and electrolytes and keep ondansetron doses low.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Ondansetron
- Apomorphine + Ondansetron Contraindicated
- Ondansetron + Thioridazine Contraindicated
- Ondansetron + Vandetanib Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Ceritinib with Ondansetron?
MediHelp rates the interaction as major. Ceritinib and Ondansetron can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ceritinib prolongs the QT interval and also inhibits CYP3A4, which can raise ondansetron exposure. Both effects increase the risk of torsades de pointes.
How serious is the interaction between Ceritinib and Ondansetron?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible and choose an antiemetic without QT effect. If used, monitor ECG and electrolytes and keep ondansetron doses low.
What other medicines interact with Ondansetron?
MediHelp also lists interactions of Ondansetron with, for example, Apomorphine, Thioridazine, Vandetanib. The full list is on the Ondansetron page.
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