Drug interactions
Ceritinib + Oxycodone
Severity: Moderate
Ceritinib and Oxycodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceritinib inhibits CYP3A4 and may raise oxycodone concentrations, increasing the risk of sedation and respiratory depression. The effect is predicted from the mechanism rather than well characterized clinically.
What this interaction means in plain words
Ceritinib and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ceritinib belongs to Oncology; Oxycodone belongs to Musculoskeletal.
Why it happens
Inhibition of CYP3A4-mediated oxycodone metabolism by ceritinib.
What to do
Monitor for opioid toxicity such as sedation and slowed breathing and reduce the oxycodone dose if needed. Reassess the dose when ceritinib is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Ceritinib with Oxycodone?
MediHelp rates the interaction as moderate. Ceritinib and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ceritinib inhibits CYP3A4 and may raise oxycodone concentrations, increasing the risk of sedation and respiratory depression. The effect is predicted from the mechanism rather than well characterized clinically.
How serious is the interaction between Ceritinib and Oxycodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for opioid toxicity such as sedation and slowed breathing and reduce the oxycodone dose if needed. Reassess the dose when ceritinib is stopped.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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