Drug interactions
Ceritinib + Ranolazine
Severity: Major
Ceritinib and Ranolazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceritinib is a CYP3A4 inhibitor and both drugs prolong the QT interval. Higher ranolazine levels together with additive QT effects raise the risk of torsades de pointes.
What this interaction means in plain words
Ceritinib and Ranolazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ceritinib belongs to Oncology; Ranolazine belongs to Cardiovascular.
Why it happens
Additive QTc prolongation plus ceritinib inhibition of CYP3A4-mediated ranolazine metabolism.
What to do
Avoid the combination where possible, and choose another antianginal. If unavoidable, monitor ECG QTc and electrolytes and limit the ranolazine dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Ceritinib with Ranolazine?
MediHelp rates the interaction as major. Ceritinib and Ranolazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ceritinib is a CYP3A4 inhibitor and both drugs prolong the QT interval. Higher ranolazine levels together with additive QT effects raise the risk of torsades de pointes.
How serious is the interaction between Ceritinib and Ranolazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, and choose another antianginal. If unavoidable, monitor ECG QTc and electrolytes and limit the ranolazine dose.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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