Drug interactions
Ceritinib + Sevoflurane
Severity: Moderate
Ceritinib and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceritinib can prolong the QT interval and cause bradycardia, and sevoflurane adds further repolarization delay. The combination may raise the risk of torsades de pointes.
What this interaction means in plain words
Ceritinib and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ceritinib belongs to Oncology; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive QTc prolongation.
What to do
Obtain a baseline ECG and correct potassium and magnesium before surgery. Monitor the ECG and heart rate intraoperatively and avoid other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sevoflurane
Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Ceritinib with Sevoflurane?
MediHelp rates the interaction as moderate. Ceritinib and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ceritinib can prolong the QT interval and cause bradycardia, and sevoflurane adds further repolarization delay. The combination may raise the risk of torsades de pointes.
How serious is the interaction between Ceritinib and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before surgery. Monitor the ECG and heart rate intraoperatively and avoid other QT-prolonging drugs.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
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