Drug interactions
Cetirizine + Danicopan
Severity: Minor
Cetirizine and Danicopan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danicopan inhibits P-glycoprotein and may increase exposure to cetirizine. Because cetirizine has a broad safety margin, the likely effect is increased drowsiness.
What this interaction means in plain words
Cetirizine and Danicopan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cetirizine belongs to Respiratory; Danicopan belongs to Miscellaneous.
Why it happens
P-glycoprotein inhibition by danicopan reduces efflux of cetirizine.
What to do
Monitor for increased sedation and consider reducing the cetirizine dose if adverse effects occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cetirizine
- Acrivastine + Cetirizine Moderate
- Amisulpride + Cetirizine Moderate
- Asenapine + Cetirizine Moderate
- Avapritinib + Cetirizine Moderate
- Benzhydrocodone / acetaminophen + Cetirizine Moderate
- Brexpiprazole + Cetirizine Moderate
Other interactions of Danicopan
- Amiodarone + Danicopan Moderate
- Apixaban + Danicopan Moderate
- Atorvastatin + Danicopan Moderate
- Brentuximab + Danicopan Moderate
- Carvedilol + Danicopan Moderate
- Cladribine + Danicopan Moderate
Frequently asked questions
Can I take Cetirizine with Danicopan?
MediHelp rates the interaction as minor. Cetirizine and Danicopan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Danicopan inhibits P-glycoprotein and may increase exposure to cetirizine. Because cetirizine has a broad safety margin, the likely effect is increased drowsiness.
How serious is the interaction between Cetirizine and Danicopan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased sedation and consider reducing the cetirizine dose if adverse effects occur.
What other medicines interact with Cetirizine?
MediHelp also lists interactions of Cetirizine with, for example, Acrivastine, Amisulpride, Asenapine. The full list is on the Cetirizine page.
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