Drug interactions
Cetirizine + Pregabalin
Severity: Minor
Cetirizine and Pregabalin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pregabalin causes dose-related somnolence and dizziness, and labeling warns of respiratory depression when it is given with other CNS depressants. Adding cetirizine may increase drowsiness and impair concentration, though the effect is generally modest.
What this interaction means in plain words
Cetirizine and Pregabalin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cetirizine belongs to Respiratory; Pregabalin belongs to Central Nervous System.
Why it happens
Additive central nervous system depression through pharmacodynamic synergism.
What to do
Use the lowest effective doses and warn the patient about sedation and driving. Monitor higher-risk patients, such as the elderly or those with respiratory disease, for excess sedation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cetirizine
- Acrivastine + Cetirizine Moderate
- Amisulpride + Cetirizine Moderate
- Asenapine + Cetirizine Moderate
- Avapritinib + Cetirizine Moderate
- Benzhydrocodone / acetaminophen + Cetirizine Moderate
- Brexpiprazole + Cetirizine Moderate
Other interactions of Pregabalin
Frequently asked questions
Can I take Cetirizine with Pregabalin?
MediHelp rates the interaction as minor. Cetirizine and Pregabalin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pregabalin causes dose-related somnolence and dizziness, and labeling warns of respiratory depression when it is given with other CNS depressants. Adding cetirizine may increase drowsiness and impair concentration, though the effect is generally modest.
How serious is the interaction between Cetirizine and Pregabalin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and warn the patient about sedation and driving. Monitor higher-risk patients, such as the elderly or those with respiratory disease, for excess sedation.
What other medicines interact with Cetirizine?
MediHelp also lists interactions of Cetirizine with, for example, Acrivastine, Amisulpride, Asenapine. The full list is on the Cetirizine page.
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