Drug interactions
Cetirizine + Stiripentol
Severity: Moderate
Cetirizine and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol may inhibit P-glycoprotein and raise cetirizine levels. Both drugs can also cause drowsiness, so sedation may be additive.
What this interaction means in plain words
Cetirizine and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cetirizine belongs to Respiratory; Stiripentol belongs to Central Nervous System.
Why it happens
P-gp inhibition by stiripentol combined with additive CNS depressant effects.
What to do
Monitor for excess sedation and reduce the cetirizine dose if adverse effects develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cetirizine
- Acrivastine + Cetirizine Moderate
- Amisulpride + Cetirizine Moderate
- Asenapine + Cetirizine Moderate
- Avapritinib + Cetirizine Moderate
- Benzhydrocodone / acetaminophen + Cetirizine Moderate
- Brexpiprazole + Cetirizine Moderate
Other interactions of Stiripentol
Frequently asked questions
Can I take Cetirizine with Stiripentol?
MediHelp rates the interaction as moderate. Cetirizine and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol may inhibit P-glycoprotein and raise cetirizine levels. Both drugs can also cause drowsiness, so sedation may be additive.
How serious is the interaction between Cetirizine and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and reduce the cetirizine dose if adverse effects develop.
What other medicines interact with Cetirizine?
MediHelp also lists interactions of Cetirizine with, for example, Acrivastine, Amisulpride, Asenapine. The full list is on the Cetirizine page.
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