Drug interactions
Chloroquine + Dolasetron
Severity: Major
Chloroquine and Dolasetron: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloroquine can markedly prolong the QT interval and has been linked to torsades de pointes, and dolasetron adds further prolongation. The combination raises the risk of serious ventricular arrhythmia, especially with hypokalemia or cardiac disease.
What this interaction means in plain words
Chloroquine and Dolasetron can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chloroquine belongs to Anti Parasitic; Dolasetron belongs to Gastrointestinal Tract.
Why it happens
Additive QT prolongation via delayed ventricular repolarization.
What to do
Avoid the combination where possible and choose an antiemetic with less QT effect. If unavoidable, monitor ECG and correct potassium and magnesium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Other interactions of Chloroquine
- Chloroquine + Cisapride Contraindicated
- Chloroquine + Dofetilide Contraindicated
- Chloroquine + Dronedarone Contraindicated
- Chloroquine + Droperidol Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chloroquine + Pimozide Contraindicated
Frequently asked questions
Can I take Chloroquine with Dolasetron?
MediHelp rates the interaction as major. Chloroquine and Dolasetron can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Chloroquine can markedly prolong the QT interval and has been linked to torsades de pointes, and dolasetron adds further prolongation. The combination raises the risk of serious ventricular arrhythmia, especially with hypokalemia or cardiac disease.
How serious is the interaction between Chloroquine and Dolasetron?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and choose an antiemetic with less QT effect. If unavoidable, monitor ECG and correct potassium and magnesium.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Ibutilide. The full list is on the Dolasetron page.
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