Drug interactions
Chloroquine + Duloxetine
Severity: Minor
Chloroquine and Duloxetine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloroquine inhibits CYP2D6 and may modestly increase duloxetine concentrations, as CYP2D6 and CYP1A2 both metabolize it. This may increase nausea, dizziness or other dose-related adverse effects.
What this interaction means in plain words
Chloroquine and Duloxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chloroquine belongs to Anti Parasitic; Duloxetine belongs to Central Nervous System.
Why it happens
CYP2D6 inhibition by chloroquine reduces duloxetine clearance.
What to do
Monitor for duloxetine adverse effects and adjust the dose if they emerge.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chloroquine
- Chloroquine + Cisapride Contraindicated
- Chloroquine + Dofetilide Contraindicated
- Chloroquine + Dronedarone Contraindicated
- Chloroquine + Droperidol Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chloroquine + Pimozide Contraindicated
Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Chloroquine with Duloxetine?
MediHelp rates the interaction as minor. Chloroquine and Duloxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chloroquine inhibits CYP2D6 and may modestly increase duloxetine concentrations, as CYP2D6 and CYP1A2 both metabolize it. This may increase nausea, dizziness or other dose-related adverse effects.
How serious is the interaction between Chloroquine and Duloxetine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for duloxetine adverse effects and adjust the dose if they emerge.
What other medicines interact with Chloroquine?
MediHelp also lists interactions of Chloroquine with, for example, Cisapride, Dofetilide, Dronedarone. The full list is on the Chloroquine page.
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