Drug interactions
Chloroquine + Fedratinib
Severity: Moderate
Chloroquine and Fedratinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib inhibits CYP3A4 and CYP2D6, both of which contribute to chloroquine metabolism. Chloroquine exposure may rise, increasing dose-related adverse effects such as QT prolongation and neuropsychiatric effects.
What this interaction means in plain words
Chloroquine and Fedratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloroquine belongs to Anti Parasitic; Fedratinib belongs to Oncology.
Why it happens
Fedratinib inhibits CYP3A4 and CYP2D6, reducing the metabolic clearance of chloroquine.
What to do
Monitor for chloroquine toxicity and consider an ECG if therapy is prolonged or other QT-prolonging drugs are used. Reduce the chloroquine dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloroquine
- Chloroquine + Cisapride Contraindicated
- Chloroquine + Dofetilide Contraindicated
- Chloroquine + Dronedarone Contraindicated
- Chloroquine + Droperidol Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chloroquine + Pimozide Contraindicated
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Chloroquine with Fedratinib?
MediHelp rates the interaction as moderate. Chloroquine and Fedratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib inhibits CYP3A4 and CYP2D6, both of which contribute to chloroquine metabolism. Chloroquine exposure may rise, increasing dose-related adverse effects such as QT prolongation and neuropsychiatric effects.
How serious is the interaction between Chloroquine and Fedratinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for chloroquine toxicity and consider an ECG if therapy is prolonged or other QT-prolonging drugs are used. Reduce the chloroquine dose if adverse effects occur.
What other medicines interact with Chloroquine?
MediHelp also lists interactions of Chloroquine with, for example, Cisapride, Dofetilide, Dronedarone. The full list is on the Chloroquine page.
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