Drug interactions
Chloroquine + Idelalisib
Severity: Moderate
Chloroquine and Idelalisib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idelalisib is a strong CYP3A inhibitor and may raise chloroquine concentrations, though CYP3A4 is only one of several routes of chloroquine clearance. Higher exposure could increase toxicity including QT prolongation.
What this interaction means in plain words
Chloroquine and Idelalisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloroquine belongs to Anti Parasitic; Idelalisib belongs to Oncology.
Why it happens
Idelalisib inhibits CYP3A4, reducing chloroquine metabolism.
What to do
Monitor for chloroquine adverse effects and consider an ECG in patients with cardiac risk factors. Consider an alternative antimalarial if prolonged therapy is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloroquine
- Chloroquine + Cisapride Contraindicated
- Chloroquine + Dofetilide Contraindicated
- Chloroquine + Dronedarone Contraindicated
- Chloroquine + Droperidol Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chloroquine + Pimozide Contraindicated
Other interactions of Idelalisib
- Alfuzosin + Idelalisib Contraindicated
- Cisapride + Idelalisib Contraindicated
- Dihydroergotamine + Idelalisib Contraindicated
- Dronedarone + Idelalisib Contraindicated
- Eletriptan + Idelalisib Contraindicated
- Eplerenone + Idelalisib Contraindicated
Frequently asked questions
Can I take Chloroquine with Idelalisib?
MediHelp rates the interaction as moderate. Chloroquine and Idelalisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Idelalisib is a strong CYP3A inhibitor and may raise chloroquine concentrations, though CYP3A4 is only one of several routes of chloroquine clearance. Higher exposure could increase toxicity including QT prolongation.
How serious is the interaction between Chloroquine and Idelalisib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for chloroquine adverse effects and consider an ECG in patients with cardiac risk factors. Consider an alternative antimalarial if prolonged therapy is needed.
What other medicines interact with Chloroquine?
MediHelp also lists interactions of Chloroquine with, for example, Cisapride, Dofetilide, Dronedarone. The full list is on the Chloroquine page.
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