Drug interactions
Chloroquine + Methamphetamine
Severity: Moderate
Chloroquine and Methamphetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloroquine inhibits CYP2D6, which is involved in methamphetamine clearance, so methamphetamine exposure may increase. This could intensify sympathomimetic effects such as tachycardia and hypertension.
What this interaction means in plain words
Chloroquine and Methamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloroquine belongs to Anti Parasitic; Methamphetamine belongs to Central Nervous System.
Why it happens
Chloroquine inhibition of CYP2D6 reduces methamphetamine metabolism.
What to do
Monitor heart rate, blood pressure, and symptoms of sympathomimetic excess. Reduce the methamphetamine dose if adverse effects develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloroquine
- Chloroquine + Cisapride Contraindicated
- Chloroquine + Dofetilide Contraindicated
- Chloroquine + Dronedarone Contraindicated
- Chloroquine + Droperidol Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chloroquine + Pimozide Contraindicated
Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Chloroquine with Methamphetamine?
MediHelp rates the interaction as moderate. Chloroquine and Methamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloroquine inhibits CYP2D6, which is involved in methamphetamine clearance, so methamphetamine exposure may increase. This could intensify sympathomimetic effects such as tachycardia and hypertension.
How serious is the interaction between Chloroquine and Methamphetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure, and symptoms of sympathomimetic excess. Reduce the methamphetamine dose if adverse effects develop.
What other medicines interact with Chloroquine?
MediHelp also lists interactions of Chloroquine with, for example, Cisapride, Dofetilide, Dronedarone. The full list is on the Chloroquine page.
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