Drug interactions
Chloroquine + Omaveloxolone
Severity: Minor
Chloroquine and Omaveloxolone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Omaveloxolone may induce CYP2C8, which contributes to chloroquine metabolism, potentially lowering chloroquine levels. The clinical impact is uncertain.
What this interaction means in plain words
Chloroquine and Omaveloxolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chloroquine belongs to Anti Parasitic; Omaveloxolone belongs to Central Nervous System.
Why it happens
Possible CYP2C8 induction by omaveloxolone increasing chloroquine clearance.
What to do
Monitor for reduced chloroquine efficacy; no routine dose adjustment is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chloroquine
- Chloroquine + Cisapride Contraindicated
- Chloroquine + Dofetilide Contraindicated
- Chloroquine + Dronedarone Contraindicated
- Chloroquine + Droperidol Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chloroquine + Pimozide Contraindicated
Other interactions of Omaveloxolone
Frequently asked questions
Can I take Chloroquine with Omaveloxolone?
MediHelp rates the interaction as minor. Chloroquine and Omaveloxolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Omaveloxolone may induce CYP2C8, which contributes to chloroquine metabolism, potentially lowering chloroquine levels. The clinical impact is uncertain.
How serious is the interaction between Chloroquine and Omaveloxolone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced chloroquine efficacy; no routine dose adjustment is needed.
What other medicines interact with Chloroquine?
MediHelp also lists interactions of Chloroquine with, for example, Cisapride, Dofetilide, Dronedarone. The full list is on the Chloroquine page.
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