Drug interactions
Chloroquine + Oxycodone
Severity: Minor
Chloroquine and Oxycodone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloroquine is a weak CYP2D6 inhibitor and could modestly alter oxycodone's conversion to oxymorphone. Because oxycodone itself is the main active moiety and is mostly cleared by CYP3A4, the clinical effect is likely small.
What this interaction means in plain words
Chloroquine and Oxycodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chloroquine belongs to Anti Parasitic; Oxycodone belongs to Musculoskeletal.
Why it happens
Weak inhibition of CYP2D6 by chloroquine may reduce formation of oxymorphone.
What to do
No routine adjustment is needed; monitor analgesic response and sedation if both are used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Other interactions of Chloroquine
- Chloroquine + Cisapride Contraindicated
- Chloroquine + Dofetilide Contraindicated
- Chloroquine + Dronedarone Contraindicated
- Chloroquine + Droperidol Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chloroquine + Pimozide Contraindicated
Frequently asked questions
Can I take Chloroquine with Oxycodone?
MediHelp rates the interaction as minor. Chloroquine and Oxycodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chloroquine is a weak CYP2D6 inhibitor and could modestly alter oxycodone's conversion to oxymorphone. Because oxycodone itself is the main active moiety and is mostly cleared by CYP3A4, the clinical effect is likely small.
How serious is the interaction between Chloroquine and Oxycodone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor analgesic response and sedation if both are used.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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