Drug interactions
Chloroquine + Ozanimod
Severity: Moderate
Chloroquine and Ozanimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod can cause bradycardia and has been associated with QT effects at higher exposures, while chloroquine prolongs the QT interval. Bradycardia increases the likelihood of torsades with QT-prolonging drugs.
What this interaction means in plain words
Chloroquine and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloroquine belongs to Anti Parasitic; Ozanimod belongs to Central Nervous System.
Why it happens
Additive QTc prolongation, aggravated by ozanimod-induced bradycardia.
What to do
Obtain a baseline ECG and monitor heart rate and QTc, especially at ozanimod initiation. Consider an alternative if QTc risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloroquine
- Chloroquine + Cisapride Contraindicated
- Chloroquine + Dofetilide Contraindicated
- Chloroquine + Dronedarone Contraindicated
- Chloroquine + Droperidol Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chloroquine + Pimozide Contraindicated
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Chloroquine with Ozanimod?
MediHelp rates the interaction as moderate. Chloroquine and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ozanimod can cause bradycardia and has been associated with QT effects at higher exposures, while chloroquine prolongs the QT interval. Bradycardia increases the likelihood of torsades with QT-prolonging drugs.
How serious is the interaction between Chloroquine and Ozanimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor heart rate and QTc, especially at ozanimod initiation. Consider an alternative if QTc risk factors are present.
What other medicines interact with Chloroquine?
MediHelp also lists interactions of Chloroquine with, for example, Cisapride, Dofetilide, Dronedarone. The full list is on the Chloroquine page.
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