Drug interactions
Chloroquine + Sevoflurane
Severity: Moderate
Chloroquine and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sevoflurane can prolong the QT interval and chloroquine has the same effect. Together they may increase the risk of perioperative torsades de pointes.
What this interaction means in plain words
Chloroquine and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloroquine belongs to Anti Parasitic; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive prolongation of ventricular repolarization.
What to do
Check ECG and electrolytes before elective anesthesia in patients on chloroquine. Maintain normal potassium and magnesium and monitor the ECG during surgery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloroquine
- Chloroquine + Cisapride Contraindicated
- Chloroquine + Dofetilide Contraindicated
- Chloroquine + Dronedarone Contraindicated
- Chloroquine + Droperidol Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chloroquine + Pimozide Contraindicated
Other interactions of Sevoflurane
Frequently asked questions
Can I take Chloroquine with Sevoflurane?
MediHelp rates the interaction as moderate. Chloroquine and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sevoflurane can prolong the QT interval and chloroquine has the same effect. Together they may increase the risk of perioperative torsades de pointes.
How serious is the interaction between Chloroquine and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and electrolytes before elective anesthesia in patients on chloroquine. Maintain normal potassium and magnesium and monitor the ECG during surgery.
What other medicines interact with Chloroquine?
MediHelp also lists interactions of Chloroquine with, for example, Cisapride, Dofetilide, Dronedarone. The full list is on the Chloroquine page.
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