Drug interactions
Chlorothiazide + Cholecalciferol
Severity: Moderate
Chlorothiazide and Cholecalciferol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics reduce urinary calcium excretion, and with vitamin D this may cause hypercalcemia. The risk is higher with high-dose vitamin D or renal impairment.
What this interaction means in plain words
Chlorothiazide and Cholecalciferol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorothiazide belongs to Cardiovascular; Cholecalciferol belongs to Musculoskeletal.
Why it happens
Thiazides increase renal calcium reabsorption while vitamin D increases intestinal calcium absorption.
What to do
Monitor serum calcium periodically. Reduce the vitamin D dose or change the diuretic if hypercalcemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cholecalciferol
- Cholecalciferol + Digoxin Major
- Aluminum hydroxide + Cholecalciferol Moderate
- Calcium acetate + Cholecalciferol Moderate
- Calcium Carbonate + Cholecalciferol Moderate
- Calcium chloride + Cholecalciferol Moderate
- Calcium citrate + Cholecalciferol Moderate
Other interactions of Chlorothiazide
Frequently asked questions
Can I take Chlorothiazide with Cholecalciferol?
MediHelp rates the interaction as moderate. Chlorothiazide and Cholecalciferol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics reduce urinary calcium excretion, and with vitamin D this may cause hypercalcemia. The risk is higher with high-dose vitamin D or renal impairment.
How serious is the interaction between Chlorothiazide and Cholecalciferol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium periodically. Reduce the vitamin D dose or change the diuretic if hypercalcemia develops.
What other medicines interact with Cholecalciferol?
MediHelp also lists interactions of Cholecalciferol with, for example, Digoxin, Aluminum hydroxide, Calcium acetate. The full list is on the Cholecalciferol page.
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