Drug interactions
Chlorothiazide + Ertugliflozin-sitagliptin
Severity: Minor
Chlorothiazide and Ertugliflozin-sitagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorothiazide may raise blood glucose and so reduce the effectiveness of the ertugliflozin-sitagliptin combination. Combined diuretic effects with ertugliflozin can also increase the risk of volume depletion and electrolyte disturbance.
What this interaction means in plain words
Chlorothiazide and Ertugliflozin-sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chlorothiazide belongs to Cardiovascular; Ertugliflozin-sitagliptin belongs to Endocrine.
Why it happens
Thiazide-induced hypokalemia and impaired insulin secretion and sensitivity oppose antihyperglycemic action; additive diuresis with SGLT2 inhibition.
What to do
Monitor blood glucose, HbA1c, potassium and volume status when starting or adjusting chlorothiazide. Modify antidiabetic treatment if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ertugliflozin-sitagliptin
Other interactions of Chlorothiazide
Frequently asked questions
Can I take Chlorothiazide with Ertugliflozin-sitagliptin?
MediHelp rates the interaction as minor. Chlorothiazide and Ertugliflozin-sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chlorothiazide may raise blood glucose and so reduce the effectiveness of the ertugliflozin-sitagliptin combination. Combined diuretic effects with ertugliflozin can also increase the risk of volume depletion and electrolyte disturbance.
How serious is the interaction between Chlorothiazide and Ertugliflozin-sitagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose, HbA1c, potassium and volume status when starting or adjusting chlorothiazide. Modify antidiabetic treatment if control worsens.
What other medicines interact with Ertugliflozin-sitagliptin?
MediHelp also lists interactions of Ertugliflozin-sitagliptin with, for example, Albiglutide, Aripiprazole, Asenapine. The full list is on the Ertugliflozin-sitagliptin page.
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