Drug interactions
Chlorpromazine + Clobazam
Severity: Moderate
Chlorpromazine and Clobazam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause CNS depression, so their combination may increase sedation, impaired coordination, and respiratory depression. Clobazam, through its active metabolite, is also a weak CYP2D6 inhibitor and may raise exposure to CYP2D6 substrates such as chlorpromazine.
What this interaction means in plain words
Chlorpromazine and Clobazam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Clobazam belongs to Central Nervous System.
Why it happens
Additive CNS depression, with weak CYP2D6 inhibition by clobazam that may modestly raise chlorpromazine levels.
What to do
Monitor sedation, respiratory status, and extrapyramidal or hypotensive effects. Reduce the chlorpromazine dose if excess effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Chlorpromazine with Clobazam?
MediHelp rates the interaction as moderate. Chlorpromazine and Clobazam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause CNS depression, so their combination may increase sedation, impaired coordination, and respiratory depression. Clobazam, through its active metabolite, is also a weak CYP2D6 inhibitor and may raise exposure to CYP2D6 substrates such as chlorpromazine.
How serious is the interaction between Chlorpromazine and Clobazam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, respiratory status, and extrapyramidal or hypotensive effects. Reduce the chlorpromazine dose if excess effects occur.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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