Drug interactions
Chlorpromazine + Dacomitinib
Severity: Moderate
Chlorpromazine and Dacomitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dacomitinib strongly inhibits CYP2D6, which is involved in chlorpromazine metabolism. Chlorpromazine levels may rise, increasing sedation, hypotension, extrapyramidal effects and QT prolongation.
What this interaction means in plain words
Chlorpromazine and Dacomitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Dacomitinib belongs to Oncology.
Why it happens
Inhibition of CYP2D6-mediated metabolism of chlorpromazine by dacomitinib.
What to do
Monitor for chlorpromazine adverse effects and consider reducing its dose. Use an alternative antipsychotic that is not a CYP2D6 substrate if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Other interactions of Dacomitinib
- Dacomitinib + Thioridazine Contraindicated
- Amitriptyline + Dacomitinib Major
- Atomoxetine + Dacomitinib Major
- Brexpiprazole + Dacomitinib Major
- Clomipramine + Dacomitinib Major
- Dacomitinib + Desipramine Major
Frequently asked questions
Can I take Chlorpromazine with Dacomitinib?
MediHelp rates the interaction as moderate. Chlorpromazine and Dacomitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dacomitinib strongly inhibits CYP2D6, which is involved in chlorpromazine metabolism. Chlorpromazine levels may rise, increasing sedation, hypotension, extrapyramidal effects and QT prolongation.
How serious is the interaction between Chlorpromazine and Dacomitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for chlorpromazine adverse effects and consider reducing its dose. Use an alternative antipsychotic that is not a CYP2D6 substrate if toxicity occurs.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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