Drug interactions
Chlorpromazine + Desflurane
Severity: Moderate
Chlorpromazine and Desflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpromazine and volatile anesthetics can each prolong the QT interval, and together they add to the arrhythmia risk during surgery. Additive hypotension and CNS depression also occur.
What this interaction means in plain words
Chlorpromazine and Desflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Desflurane belongs to Central Nervous System.
Why it happens
Additive QT prolongation and additive CNS and cardiovascular depression.
What to do
Inform the anesthesia team of chlorpromazine use and check the baseline QTc. Keep electrolytes normal and monitor ECG and blood pressure perioperatively.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Other interactions of Desflurane
Frequently asked questions
Can I take Chlorpromazine with Desflurane?
MediHelp rates the interaction as moderate. Chlorpromazine and Desflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpromazine and volatile anesthetics can each prolong the QT interval, and together they add to the arrhythmia risk during surgery. Additive hypotension and CNS depression also occur.
How serious is the interaction between Chlorpromazine and Desflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team of chlorpromazine use and check the baseline QTc. Keep electrolytes normal and monitor ECG and blood pressure perioperatively.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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