Drug interactions
Chlorpromazine + Difelikefalin
Severity: Moderate
Chlorpromazine and Difelikefalin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Difelikefalin can cause somnolence and dizziness, and chlorpromazine is strongly sedating. Together they may increase drowsiness and the risk of falls.
What this interaction means in plain words
Chlorpromazine and Difelikefalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Difelikefalin belongs to Dermatology.
Why it happens
Additive CNS depression; difelikefalin is a peripherally restricted kappa-opioid agonist with some CNS effects.
What to do
Monitor for excess sedation, dizziness and falls, particularly in dialysis patients, and reduce doses if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Other interactions of Difelikefalin
- Acetazolamide + Difelikefalin Moderate
- Alprazolam + Difelikefalin Moderate
- Amantadine + Difelikefalin Moderate
- Amitriptyline + Difelikefalin Moderate
- Amobarbital + Difelikefalin Moderate
- Asenapine + Difelikefalin Moderate
Frequently asked questions
Can I take Chlorpromazine with Difelikefalin?
MediHelp rates the interaction as moderate. Chlorpromazine and Difelikefalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Difelikefalin can cause somnolence and dizziness, and chlorpromazine is strongly sedating. Together they may increase drowsiness and the risk of falls.
How serious is the interaction between Chlorpromazine and Difelikefalin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation, dizziness and falls, particularly in dialysis patients, and reduce doses if needed.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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