Drug interactions
Chlorpromazine + Eliglustat
Severity: Major
Chlorpromazine and Eliglustat: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpromazine inhibits CYP2D6, the main enzyme metabolizing eliglustat, so eliglustat concentrations may increase. Higher exposure can prolong PR, QRS and QT intervals and cause arrhythmias.
What this interaction means in plain words
Chlorpromazine and Eliglustat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chlorpromazine belongs to Central Nervous System; Eliglustat belongs to Miscellaneous.
Why it happens
Chlorpromazine inhibits CYP2D6-mediated metabolism of eliglustat, and both can prolong QT.
What to do
Reduce eliglustat dose per labeling for CYP2D6 inhibitors in eligible patients and monitor ECG; avoid if additional CYP3A inhibitors are also used.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Eliglustat?
MediHelp rates the interaction as major. Chlorpromazine and Eliglustat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Chlorpromazine inhibits CYP2D6, the main enzyme metabolizing eliglustat, so eliglustat concentrations may increase. Higher exposure can prolong PR, QRS and QT intervals and cause arrhythmias.
How serious is the interaction between Chlorpromazine and Eliglustat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce eliglustat dose per labeling for CYP2D6 inhibitors in eligible patients and monitor ECG; avoid if additional CYP3A inhibitors are also used.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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