Drug interactions
Chlorpromazine + Eluxadoline
Severity: Minor
Chlorpromazine and Eluxadoline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpromazine is a CYP2D6 inhibitor, and eluxadoline metabolism is incompletely characterized, so exposure to eluxadoline may rise. The clinical relevance is uncertain and mainly theoretical.
What this interaction means in plain words
Chlorpromazine and Eluxadoline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chlorpromazine belongs to Central Nervous System; Eluxadoline belongs to Gastrointestinal Tract.
Why it happens
Possible inhibition of CYP2D6-mediated metabolism of eluxadoline by chlorpromazine.
What to do
No routine adjustment is needed; monitor for eluxadoline adverse effects such as constipation, abdominal pain and sedation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Other interactions of Eluxadoline
Frequently asked questions
Can I take Chlorpromazine with Eluxadoline?
MediHelp rates the interaction as minor. Chlorpromazine and Eluxadoline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chlorpromazine is a CYP2D6 inhibitor, and eluxadoline metabolism is incompletely characterized, so exposure to eluxadoline may rise. The clinical relevance is uncertain and mainly theoretical.
How serious is the interaction between Chlorpromazine and Eluxadoline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for eluxadoline adverse effects such as constipation, abdominal pain and sedation.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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