Drug interactions
Chlorpromazine + Etomidate
Severity: Moderate
Chlorpromazine and Etomidate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpromazine can add to the sedative and hypotensive effects of etomidate during anesthesia. Recovery may be prolonged and blood pressure may fall further.
What this interaction means in plain words
Chlorpromazine and Etomidate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Etomidate belongs to Central Nervous System.
Why it happens
Additive CNS depression and alpha-adrenergic blockade.
What to do
Titrate etomidate carefully and monitor blood pressure and airway during induction. Be prepared to support hemodynamics.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Other interactions of Etomidate
- Alprazolam + Etomidate Moderate
- Amitriptyline + Etomidate Moderate
- Amobarbital + Etomidate Moderate
- Azelastine + Etomidate Moderate
- Baclofen + Etomidate Moderate
- Brompheniramine + Etomidate Moderate
Frequently asked questions
Can I take Chlorpromazine with Etomidate?
MediHelp rates the interaction as moderate. Chlorpromazine and Etomidate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpromazine can add to the sedative and hypotensive effects of etomidate during anesthesia. Recovery may be prolonged and blood pressure may fall further.
How serious is the interaction between Chlorpromazine and Etomidate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate etomidate carefully and monitor blood pressure and airway during induction. Be prepared to support hemodynamics.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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