Drug interactions
Chlorpromazine + Fluvoxamine
Severity: Moderate
Chlorpromazine and Fluvoxamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluvoxamine may raise chlorpromazine exposure through CYP inhibition, increasing sedation, hypotension and anticholinergic effects. Chlorpromazine also prolongs the QT interval, which adds to risk in susceptible patients.
What this interaction means in plain words
Chlorpromazine and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Fluvoxamine belongs to Central Nervous System.
Why it happens
Inhibition of CYP1A2 and CYP2D6 metabolism of chlorpromazine, with additive QT and sedative effects.
What to do
Monitor for sedation, hypotension and extrapyramidal symptoms, and obtain an ECG if other QT risk factors exist. Reduce the chlorpromazine dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Fluvoxamine?
MediHelp rates the interaction as moderate. Chlorpromazine and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluvoxamine may raise chlorpromazine exposure through CYP inhibition, increasing sedation, hypotension and anticholinergic effects. Chlorpromazine also prolongs the QT interval, which adds to risk in susceptible patients.
How serious is the interaction between Chlorpromazine and Fluvoxamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, hypotension and extrapyramidal symptoms, and obtain an ECG if other QT risk factors exist. Reduce the chlorpromazine dose if adverse effects appear.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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