Drug interactions
Chlorpromazine + Gilteritinib
Severity: Major
Chlorpromazine and Gilteritinib: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gilteritinib and chlorpromazine can each prolong the QT interval, so together they increase the chance of serious ventricular arrhythmias including torsade de pointes. Patients with leukemia often have electrolyte disturbances that add to the risk.
What this interaction means in plain words
Chlorpromazine and Gilteritinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chlorpromazine belongs to Central Nervous System; Gilteritinib belongs to Oncology.
Why it happens
Additive QT prolongation through effects on cardiac repolarization.
What to do
Avoid if possible and consider a non-QT-prolonging alternative. If both are required, monitor ECG and keep potassium and magnesium in the normal range.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Other interactions of Gilteritinib
- Gilteritinib + Pimozide Contraindicated
- Amiodarone + Gilteritinib Major
- Amisulpride + Gilteritinib Major
- Amitriptyline + Gilteritinib Major
- Anagrelide + Gilteritinib Major
- Apalutamide + Gilteritinib Major
Frequently asked questions
Can I take Chlorpromazine with Gilteritinib?
MediHelp rates the interaction as major. Chlorpromazine and Gilteritinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Gilteritinib and chlorpromazine can each prolong the QT interval, so together they increase the chance of serious ventricular arrhythmias including torsade de pointes. Patients with leukemia often have electrolyte disturbances that add to the risk.
How serious is the interaction between Chlorpromazine and Gilteritinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible and consider a non-QT-prolonging alternative. If both are required, monitor ECG and keep potassium and magnesium in the normal range.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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