Drug interactions
Chlorpromazine + Iloprost
Severity: Moderate
Chlorpromazine and Iloprost: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs lower blood pressure, chlorpromazine through alpha-adrenergic blockade and iloprost through direct vasodilation. Taken together they can cause additive hypotension, dizziness and syncope, particularly when iloprost is given intravenously.
What this interaction means in plain words
Chlorpromazine and Iloprost can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Iloprost belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic hypotensive effects from alpha-1 blockade (chlorpromazine) and prostacyclin-mediated vasodilation (iloprost).
What to do
Monitor blood pressure and heart rate closely when starting or titrating iloprost in patients taking chlorpromazine. If hypotension occurs, reduce the iloprost dose or interrupt other blood-pressure-lowering drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Other interactions of Iloprost
- Aldesleukin + Iloprost Moderate
- Amiodarone + Iloprost Moderate
- Bortezomib + Iloprost Moderate
- Bromocriptine + Iloprost Moderate
- Bupivacaine + Iloprost Moderate
- Carbidopa-entacapone-levodopa + Iloprost Moderate
Frequently asked questions
Can I take Chlorpromazine with Iloprost?
MediHelp rates the interaction as moderate. Chlorpromazine and Iloprost can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs lower blood pressure, chlorpromazine through alpha-adrenergic blockade and iloprost through direct vasodilation. Taken together they can cause additive hypotension, dizziness and syncope, particularly when iloprost is given intravenously.
How serious is the interaction between Chlorpromazine and Iloprost?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate closely when starting or titrating iloprost in patients taking chlorpromazine. If hypotension occurs, reduce the iloprost dose or interrupt other blood-pressure-lowering drugs.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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