Drug interactions
Chlorpromazine + Imidapril
Severity: Moderate
Chlorpromazine and Imidapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpromazine can cause orthostatic hypotension, and ACE inhibitors such as imidapril lower blood pressure, so the antihypertensive effect may be enhanced. Dizziness and falls are possible, especially in older adults.
What this interaction means in plain words
Chlorpromazine and Imidapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Imidapril belongs to Cardiovascular.
Why it happens
Additive hypotensive effects from alpha-adrenergic blockade by chlorpromazine and ACE inhibition by imidapril.
What to do
Monitor blood pressure, including standing measurements, when starting or adjusting either drug. Reduce the antihypertensive dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Other interactions of Imidapril
- Amiloride + Imidapril Major
- Eplerenone + Imidapril Major
- Imidapril + Lithium Major
- Imidapril + Pregabalin Major
- Imidapril + Spironolactone Major
- Imidapril + Triamterene Major
Frequently asked questions
Can I take Chlorpromazine with Imidapril?
MediHelp rates the interaction as moderate. Chlorpromazine and Imidapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpromazine can cause orthostatic hypotension, and ACE inhibitors such as imidapril lower blood pressure, so the antihypertensive effect may be enhanced. Dizziness and falls are possible, especially in older adults.
How serious is the interaction between Chlorpromazine and Imidapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, including standing measurements, when starting or adjusting either drug. Reduce the antihypertensive dose if symptomatic hypotension occurs.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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