Drug interactions
Chlorpromazine + Indacaterol-glycopyrronium
Severity: Moderate
Chlorpromazine and Indacaterol-glycopyrronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpromazine has strong anticholinergic activity and prolongs the QT interval, which may add to glycopyrronium's antimuscarinic effects and to indacaterol's cardiac effects. This may increase anticholinergic adverse effects and arrhythmia risk.
What this interaction means in plain words
Chlorpromazine and Indacaterol-glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Indacaterol-glycopyrronium belongs to Respiratory.
Why it happens
Additive antimuscarinic effects and additive QT prolongation or adrenergic cardiac stimulation.
What to do
Monitor for anticholinergic effects and obtain an ECG in patients with QT risk factors. Correct potassium and magnesium abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Indacaterol-glycopyrronium?
MediHelp rates the interaction as moderate. Chlorpromazine and Indacaterol-glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpromazine has strong anticholinergic activity and prolongs the QT interval, which may add to glycopyrronium's antimuscarinic effects and to indacaterol's cardiac effects. This may increase anticholinergic adverse effects and arrhythmia risk.
How serious is the interaction between Chlorpromazine and Indacaterol-glycopyrronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects and obtain an ECG in patients with QT risk factors. Correct potassium and magnesium abnormalities.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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