Drug interactions
Chlorpromazine + Liraglutide
Severity: Moderate
Chlorpromazine and Liraglutide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpromazine can raise blood glucose and cause weight gain, which may counteract the glycemic and weight benefits of liraglutide. Glucose control may shift when chlorpromazine is started, changed or stopped.
What this interaction means in plain words
Chlorpromazine and Liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Liraglutide belongs to Endocrine.
Why it happens
Phenothiazine-induced impairment of glucose tolerance and weight gain opposes the effects of liraglutide.
What to do
Monitor blood glucose and HbA1c when chlorpromazine is started or adjusted. Adjust the antidiabetic regimen as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Other interactions of Liraglutide
Frequently asked questions
Can I take Chlorpromazine with Liraglutide?
MediHelp rates the interaction as moderate. Chlorpromazine and Liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpromazine can raise blood glucose and cause weight gain, which may counteract the glycemic and weight benefits of liraglutide. Glucose control may shift when chlorpromazine is started, changed or stopped.
How serious is the interaction between Chlorpromazine and Liraglutide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c when chlorpromazine is started or adjusted. Adjust the antidiabetic regimen as needed.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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