Drug interactions
Chlorpromazine + Lurasidone
Severity: Moderate
Chlorpromazine and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are antipsychotics that cause sedation, orthostatic hypotension and extrapyramidal effects, so combined use increases these adverse effects. Chlorpromazine may also add to QT effects, although lurasidone has little QT liability.
What this interaction means in plain words
Chlorpromazine and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Lurasidone belongs to Central Nervous System.
Why it happens
Additive dopamine D2 and alpha-adrenergic antagonism and CNS depression.
What to do
Use the lowest effective doses and monitor for sedation, orthostasis and movement disorders. Check an ECG if other QT-prolonging risk factors exist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Lurasidone?
MediHelp rates the interaction as moderate. Chlorpromazine and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents are antipsychotics that cause sedation, orthostatic hypotension and extrapyramidal effects, so combined use increases these adverse effects. Chlorpromazine may also add to QT effects, although lurasidone has little QT liability.
How serious is the interaction between Chlorpromazine and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for sedation, orthostasis and movement disorders. Check an ECG if other QT-prolonging risk factors exist.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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