Drug interactions
Chlorpromazine + Mirabegron
Severity: Moderate
Chlorpromazine and Mirabegron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpromazine is metabolized by CYP2D6 among other pathways, so mirabegron may increase its levels. This could increase sedation, hypotension, anticholinergic effects and QT prolongation.
What this interaction means in plain words
Chlorpromazine and Mirabegron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Mirabegron belongs to Genitourinary.
Why it happens
Moderate CYP2D6 inhibition by mirabegron reduces chlorpromazine clearance.
What to do
Monitor for sedation, orthostatic hypotension and anticholinergic effects. Reduce the chlorpromazine dose if adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirabegron
- Digoxin + Mirabegron Major
- Flecainide + Mirabegron Major
- Mirabegron + Propafenone Major
- Mirabegron + Thioridazine Major
- Amitriptyline + Mirabegron Moderate
- Amoxapine + Mirabegron Moderate
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Mirabegron?
MediHelp rates the interaction as moderate. Chlorpromazine and Mirabegron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpromazine is metabolized by CYP2D6 among other pathways, so mirabegron may increase its levels. This could increase sedation, hypotension, anticholinergic effects and QT prolongation.
How serious is the interaction between Chlorpromazine and Mirabegron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, orthostatic hypotension and anticholinergic effects. Reduce the chlorpromazine dose if adverse effects emerge.
What other medicines interact with Mirabegron?
MediHelp also lists interactions of Mirabegron with, for example, Digoxin, Flecainide, Propafenone. The full list is on the Mirabegron page.
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