Drug interactions
Chlorpromazine + Nabilone
Severity: Moderate
Chlorpromazine and Nabilone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpromazine is strongly sedating and can cause hypotension and anticholinergic effects, while nabilone adds drowsiness, dizziness and tachycardia. The combination may cause marked sedation and orthostatic symptoms.
What this interaction means in plain words
Chlorpromazine and Nabilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Nabilone belongs to Gastrointestinal Tract.
Why it happens
Additive central nervous system depression and cardiovascular effects through pharmacodynamic synergy.
What to do
Start nabilone at a low dose and monitor sedation and blood pressure, including standing measurements. Counsel patients on fall risk and avoid alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabilone
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Nabilone?
MediHelp rates the interaction as moderate. Chlorpromazine and Nabilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpromazine is strongly sedating and can cause hypotension and anticholinergic effects, while nabilone adds drowsiness, dizziness and tachycardia. The combination may cause marked sedation and orthostatic symptoms.
How serious is the interaction between Chlorpromazine and Nabilone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start nabilone at a low dose and monitor sedation and blood pressure, including standing measurements. Counsel patients on fall risk and avoid alcohol.
What other medicines interact with Nabilone?
MediHelp also lists interactions of Nabilone with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Nabilone page.
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