Drug interactions
Chlorpromazine + OnabotulinumtoxinA
Severity: Minor
Chlorpromazine and OnabotulinumtoxinA: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drugs with anticholinergic activity may potentiate the neuromuscular effects of botulinum toxin. This could lead to excessive weakness or systemic anticholinergic effects, though the risk is generally low.
What this interaction means in plain words
Chlorpromazine and OnabotulinumtoxinA have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chlorpromazine belongs to Central Nervous System; OnabotulinumtoxinA belongs to Musculoskeletal.
Why it happens
Theoretical additive anticholinergic and neuromuscular blocking effects.
What to do
Monitor for excessive muscle weakness, swallowing or breathing difficulty after injection, and use the lowest effective toxin dose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Other interactions of OnabotulinumtoxinA
Frequently asked questions
Can I take Chlorpromazine with OnabotulinumtoxinA?
MediHelp rates the interaction as minor. Chlorpromazine and OnabotulinumtoxinA have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Drugs with anticholinergic activity may potentiate the neuromuscular effects of botulinum toxin. This could lead to excessive weakness or systemic anticholinergic effects, though the risk is generally low.
How serious is the interaction between Chlorpromazine and OnabotulinumtoxinA?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive muscle weakness, swallowing or breathing difficulty after injection, and use the lowest effective toxin dose.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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