Drug interactions
Chlorpromazine + Peginterferon alfa 2b
Severity: Minor
Chlorpromazine and Peginterferon alfa 2b: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Peginterferon alfa 2b may modestly alter CYP2D6-mediated chlorpromazine metabolism, with an uncertain direction. Clinical impact is likely small, but sedation or hypotension could change.
What this interaction means in plain words
Chlorpromazine and Peginterferon alfa 2b have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chlorpromazine belongs to Central Nervous System; Peginterferon alfa 2b belongs to Anti Virals.
Why it happens
Possible interferon modulation of CYP2D6; not firmly established.
What to do
Monitor sedation, blood pressure and psychiatric response. Adjust the chlorpromazine dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Peginterferon alfa 2b
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Peginterferon alfa 2b?
MediHelp rates the interaction as minor. Chlorpromazine and Peginterferon alfa 2b have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Peginterferon alfa 2b may modestly alter CYP2D6-mediated chlorpromazine metabolism, with an uncertain direction. Clinical impact is likely small, but sedation or hypotension could change.
How serious is the interaction between Chlorpromazine and Peginterferon alfa 2b?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, blood pressure and psychiatric response. Adjust the chlorpromazine dose if needed.
What other medicines interact with Peginterferon alfa 2b?
MediHelp also lists interactions of Peginterferon alfa 2b with, for example, Aldesleukin, Deferiprone, Pexidartinib. The full list is on the Peginterferon alfa 2b page.
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