Drug interactions
Chlorpromazine + Pentazocine
Severity: Moderate
Chlorpromazine and Pentazocine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pentazocine is an opioid agonist-antagonist and chlorpromazine is a sedating phenothiazine. Taken together they can produce greater drowsiness, hypotension and respiratory depression than either drug alone.
What this interaction means in plain words
Chlorpromazine and Pentazocine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Pentazocine belongs to Musculoskeletal.
Why it happens
Additive central nervous system depression, with added alpha-adrenergic blockade from chlorpromazine contributing to hypotension.
What to do
Start with lower doses of each drug and monitor sedation, blood pressure and respiratory rate. Advise patients to avoid driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pentazocine
- Calcium / magnesium / potassium / sodium oxybates + Pentazocine Contraindicated
- Olanzapine / samidorphan + Pentazocine Contraindicated
- Pentazocine + Phenelzine Contraindicated
- Pentazocine + Tranylcypromine Contraindicated
- Alfentanil + Pentazocine Major
- Alprazolam + Pentazocine Major
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Pentazocine?
MediHelp rates the interaction as moderate. Chlorpromazine and Pentazocine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pentazocine is an opioid agonist-antagonist and chlorpromazine is a sedating phenothiazine. Taken together they can produce greater drowsiness, hypotension and respiratory depression than either drug alone.
How serious is the interaction between Chlorpromazine and Pentazocine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with lower doses of each drug and monitor sedation, blood pressure and respiratory rate. Advise patients to avoid driving and alcohol.
What other medicines interact with Pentazocine?
MediHelp also lists interactions of Pentazocine with, for example, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan, Phenelzine. The full list is on the Pentazocine page.
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